It took just two minutes for Indiana to regain control of the game, going 75 yards in nine plays to make it 24-14 with 4:26 to play in the first half.
Cameron Coffman hit Shane Wynn on a 17-yard touchdown pass to extend the lead.
After the play, Denzel Drone was flagged for a personal foul, the sixth of the half for the Spartans.
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